I am always interested in research and technology development that challenges the status quo, and gives an alternative way to do things, preferably using a computer algorithm. The paper by Bartosz Grzybowski and co-workers is one of these (see http://onlinelibrary.wiley.com/doi/10.1002/anie.201202155/abstract). One Pot reactions is currently more of an individual skill rather than a rigorous process that can be implemented in a computer algorithm. The paper published in Angewandte Chemie in 2012, address this exact issue. I am sure that this is a solvable problem, and when it does get mass acceptance, a lot of cost savings may be achieved.
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